{"id":11308,"date":"2011-01-07T02:51:46","date_gmt":"2011-01-07T02:51:46","guid":{"rendered":"http:\/\/www.mixedracestudies.org\/wordpress\/?p=11308"},"modified":"2011-01-09T01:29:54","modified_gmt":"2011-01-09T01:29:54","slug":"genetic-linkage-of-the-dentinogenesis-imperfecta-type-iii-locus-to-chromosome-4q","status":"publish","type":"post","link":"https:\/\/mixedracestudies.org\/wp\/?p=11308","title":{"rendered":"Genetic Linkage of the Dentinogenesis Imperfecta Type III Locus to Chromosome 4q"},"content":{"rendered":"

Genetic Linkage of the Dentinogenesis Imperfecta Type III Locus to Chromosome 4q<\/a><\/em><\/strong><\/p>\n

Journal of Dental Research<\/a>
\nVolume 78, Number 6<\/a> (June 1999)
\npages 1277-1282
\nDOI: 10.1177\/00220345990780061301<\/a><\/p>\n

M. MacDougall
\n<\/strong>Department of Pediatric Dentistry
\nUniversity of Texas Health Science Center, San Antonio<\/em><\/p>\n

L. G. Jeffords
\n<\/strong>Department of Pediatric Dentistry,
\nUniversity of Texas Health Science Center, San Antonio<\/em><\/p>\n

T. T. Gu
\n<\/strong>Department of Pediatric Dentistry
\nUniversity of Texas Health Science Center, San Antonio<\/em><\/p>\n

C. B. Knight
\n<\/strong>Department of Pediatric Dentistry
\nUniversity of Texas Health Science Center, San Antonio<\/em><\/p>\n

G. Frei
\n<\/strong>Department of Pediatric Dentistry,
\nUniversity of Texas Health Science Center, San Antonio<\/em><\/p>\n

B. E. Reus
\n<\/strong>Department of Cellular and Structural Biology
\nUniversity of Texas Health Science Center, San Antonio<\/em><\/p>\n

B. Otterud
\n<\/strong>Department of Human Genetics
\nEccles Institute of Human Genetics
\nUniversity of Utah School of Medicine, Salt Lake City<\/em><\/p>\n

M. Leppert
\n<\/strong>Department of Human Genetics
\nEccles Institute of Human Genetics
\nUniversity of Utah School of Medicine, Salt Lake City<\/em><\/p>\n

R. J. Leach<\/strong>
\nDepartment of Cellular and Structural Biology
\nUniversity of Texas Health Science Center, San Antonio<\/em><\/p>\n

Dentinogenesis imperfecta type III (DGI-III)<\/a> is an autosomal-dominant disorder of dentin formation which appears in a tri-racial<\/a> southern Maryland<\/a> population known as the “Brandywine isolate”. This disease has suggestive evidence of linkage to the long arm of human chromosome 4 (LOD score of 2.0) in a family presenting with both juvenile periodontitis and DGI-III. The purpose of this study was to screen a family presenting with only DGI-III to determine if this locus was indeed on chromosome 4q. Furthermore, we wanted to determine if DGI-III co-localized with dentinogenesis imperfecta type II (DGI-II), which has been localized to 4q21-q23. Therefore, a large kindred from the Brandywine isolate was identified, oral examination performed, and blood samples collected from 21 family members. DNA from this family was genotyped with 6 highly polymorphic markers that span the DGI-II critical region of chromosome 4q. Analysis of the data yielded a maximum two-point LOD score of 4.87 with a marker for the dentin matrix protein 1 (DMP1) locus, a gene contained in the critical region for DGI-II. Our results demonstrated that the DGI-III locus is on human chromosome 4q21 within a 6.6 cM region that overlaps the DGI-II critical region. These results are consistent with the hypothesis that DGI-II is either an allelic variant of DGI-III or the result of mutations in two tightly linked genes.<\/p>\n

Read or purchase the article here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Genetic Linkage of the Dentinogenesis Imperfecta Type III Locus to Chromosome 4q Journal of Dental Research Volume 78, Number 6 (June 1999) pages 1277-1282 DOI: 10.1177\/00220345990780061301 M. MacDougall Department of Pediatric Dentistry University of Texas Health Science Center, San Antonio L. G. Jeffords Department of Pediatric Dentistry, University of Texas Health Science Center, San Antonio […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,2039,8,5113,20],"tags":[5086,5087,5084,5079,5085,5080,5082,5088,5081,5089,5083],"class_list":["post-11308","post","type-post","status-publish","format-standard","hentry","category-articles","category-health-medicine","category-media-archive","category-triracial","category-usa","tag-b-e-reus","tag-b-otterud","tag-c-b-knight","tag-dentinogenesis-imperfecta-type-iii","tag-g-frei","tag-journal-of-dental-research","tag-l-g-jeffords","tag-m-leppert","tag-m-macdougall","tag-r-j-leach","tag-t-t-gu"],"_links":{"self":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/11308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11308"}],"version-history":[{"count":0,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/11308\/revisions"}],"wp:attachment":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}