{"id":18835,"date":"2011-12-09T03:44:12","date_gmt":"2011-12-09T03:44:12","guid":{"rendered":"http:\/\/www.mixedracestudies.org\/wordpress\/?p=18835"},"modified":"2011-12-09T03:54:49","modified_gmt":"2011-12-09T03:54:49","slug":"self-reported-race-and-genetic-admixture","status":"publish","type":"post","link":"https:\/\/mixedracestudies.org\/wp\/?p=18835","title":{"rendered":"Self-Reported Race and Genetic Admixture"},"content":{"rendered":"

Self-Reported Race and Genetic Admixture<\/a><\/em><\/strong><\/p>\n

The New England Journal of Medicine<\/a>
\nNumber 354, Number 4<\/a> (2006-01-26)
\npages 431-422
\nDOI: 10.1056\/NEJMc052515<\/a><\/p>\n

Moumita Sinha, M.Stat.<\/strong>
\nCase Western Reserve University, Cleveland, Ohio<\/em><\/p>\n

Emma K. Larkin, M.H.S.
\n<\/strong>Case Western Reserve University, Cleveland, Ohio<\/em><\/p>\n

Robert C. Elston, Ph.D.
\n<\/strong>Case Western Reserve University, Cleveland, Ohio<\/em><\/p>\n

Susan Redline, M.D., M.P.H.<\/strong>
\nCase Western Reserve University, Cleveland, Ohio<\/em><\/p>\n

To the Editor:<\/p>\n

The use of data on self-reported race in health research has been highly debated. For example, Burchard et al<\/em>. recently argued that important information on disease susceptibility may be derived from the use of data on self-reported race, whereas Cooper et al<\/em>. cited Wilson et al.<\/em>, who argued that ethnic labels \u201care inaccurate representations of the inferred genetic clusters.\u201d Cooper et al.<\/em>, however, ignored later work that identified limitations in the analyses of Wilson et al.<\/em> \u2014 specifically, inappropriate classification of groups, the use of a suboptimal model for cluster identification, and reliance on only 39 microsatellite<\/a> markers for cluster analyses. With larger numbers of markers, it was shown that genetically distinct groups can be almost completely inferred from self-reported race…<\/p>\n

…With support from a U.S. Public Health Service grant, we applied an admixture analysis to a sample population in Cleveland<\/a>. Participants were clearly separated into unique groups with the use of this genetic approach. Whereas 93 percent of self-reported whites were classified as having predominantly European ancestry, less than 2 percent of blacks were so classified. Only 4 percent who reported their race as black had predominantly African ancestry; yet, the admixture proportions of this group made it possible to separate the population into two groups, in which 94 percent of self-reported blacks and 7 percent of self-reported whites were classified as being of mixed race (Figure 1: Frequency Histogram Showing the Percentage of African Ancestry in a Population Living in Cleveland<\/em>). The sharp peak at the left in Figure 1 indicates that there are many persons who have no African ancestry (i.e., the values correspond to those of self-reported whites), and the broad peak at the right indicates that most blacks are of mixed race and do not originate from any single population.<\/strong> Thus, self-reported race and genetic ethnic ancestry appear to be highly correlated as a dichotomy, with those who self-report as being black comprising, as expected from historical and cultural practices in the United States, a broad range of African ancestry…<\/p>\n

Read the entire letter here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Self-Reported Race and Genetic Admixture The New England Journal of Medicine Number 354, Number 4 (2006-01-26) pages 431-422 DOI: 10.1056\/NEJMc052515 Moumita Sinha, M.Stat. Case Western Reserve University, Cleveland, Ohio Emma K. Larkin, M.H.S. Case Western Reserve University, Cleveland, Ohio Robert C. Elston, Ph.D. Case Western Reserve University, Cleveland, Ohio Susan Redline, M.D., M.P.H. Case Western […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,2039,8,20],"tags":[8626,8624,8625,8622,3277,260,4485,4486,8623,8621],"class_list":["post-18835","post","type-post","status-publish","format-standard","hentry","category-articles","category-health-medicine","category-media-archive","category-usa","tag-cleveland","tag-emma-k-larkin","tag-emma-larkin","tag-moumita-sinha","tag-new-england-journal-of-medicine","tag-ohio","tag-robert-c-elston","tag-robert-elston","tag-susan-redline","tag-the-new-england-journal-of-medicine"],"_links":{"self":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/18835","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18835"}],"version-history":[{"count":0,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/18835\/revisions"}],"wp:attachment":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18835"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18835"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}