{"id":20814,"date":"2012-02-23T22:48:53","date_gmt":"2012-02-23T22:48:53","guid":{"rendered":"http:\/\/www.mixedracestudies.org\/wordpress\/?p=20814"},"modified":"2012-02-23T22:52:25","modified_gmt":"2012-02-23T22:52:25","slug":"interethnic-diversity-of-nat2-polymorphisms-in-brazilian-admixed-populations","status":"publish","type":"post","link":"https:\/\/mixedracestudies.org\/wp\/?p=20814","title":{"rendered":"Interethnic diversity of NAT2 polymorphisms in Brazilian admixed populations"},"content":{"rendered":"

Interethnic diversity of NAT2 polymorphisms in Brazilian admixed populations<\/a><\/strong><\/em><\/p>\n

BMC Genetics<\/a>
\nVolume 11, Number 1<\/a> (2010-10-05)
\npages 87-93
\nDOI: 10.1186\/1471-2156-11-87<\/a><\/p>\n

Jhimmy Talbot<\/strong>
\nLaborat\u00f3rio de Farmacogen\u00f4mica e Epidemiologia Molecular
\nUniversidade Estadual de Santa Cruz<\/em><\/p>\n

Luiz Alexandre V. Magno<\/strong>
\nLaborat\u00f3rio de Farmacogen\u00f4mica e Epidemiologia Molecular
\nUniversidade Estadual de Santa Cruz<\/em><\/p>\n

Cinthia VN Santana<\/strong>
\nLaborat\u00f3rio de Farmacogen\u00f4mica e Epidemiologia Molecular
\nUniversidade Estadual de Santa Cruz<\/em><\/p>\n

Sandra MB Sousa<\/strong>
\nLaborat\u00f3rio de Farmacogen\u00f4mica e Epidemiologia Molecular
\nUniversidade Estadual de Santa Cruz<\/em><\/p>\n

Paulo RS Melo<\/strong>
\nLaborat\u00f3rio de Farmacogen\u00f4mica e Epidemiologia Molecular
\nUniversidade Estadual de Santa Cruz<\/em><\/p>\n

Ronan X. Correa
\n<\/strong>Laborat\u00f3rio de Farmacogen\u00f4mica e Epidemiologia Molecular
\nUniversidade Estadual de Santa Cruz<\/em><\/p>\n

Giuliano Di Pietro
\n<\/strong>Laborat\u00f3rio de Farmacogen\u00f4mica e Epidemiologia Molecular
\nUniversidade Estadual de Santa Cruz<\/em><\/p>\n

Fabr\u00edcio Rios-Santos
\n<\/strong>Laborat\u00f3rio de Farmacogen\u00f4mica e Epidemiologia Molecular
\nUniversidade Estadual de Santa Cruz<\/em><\/p>\n

Background<\/strong><\/p>\n

N-acetyltransferase type 2<\/a> (Nat2) is a phase II drug- metabolizing enzyme that plays a key role in the bioactivation<\/a> of aromatic<\/a> and heterocyclic amines<\/a>. Its relevance in drug metabolism<\/a> and disease susceptibility remains a central theme for pharmacogenetic<\/a> research, mainly because of its genetic variability among human populations. In fact, the evolutionary and ethnic-specific SNPs<\/a> on the NAT2<\/em> gene remain a focus for the potential discoveries in personalized drug therapy and genetic markers of diseases. Despite the wide characterization of NAT2<\/em> SNPs frequency in established ethnic groups, little data are available for highly admixed populations. In this context, five common NAT2<\/em> SNPs (G191A<\/em>, C481T<\/em>, G590A<\/em>, A803G<\/em> and G857A<\/em>) were investigated in a highly admixed population comprised of Afro-Brazilians, Whites, and Amerindians in northeastern Brazil. Thus, we sought to determine whether the distribution of NAT2<\/em> polymorphism is different among these three ethnic groups.<\/p>\n

Results<\/strong><\/p>\n

Overall, there were no statistically significant differences in the distribution of NAT2<\/em> polymorphism when Afro-Brazilian and White groups were compared. Even the allele frequency of 191A<\/em>, relatively common in African descendents, was not different between the Afro-Brazilian and White groups. However, allele and genotype frequencies of G590A<\/em> were significantly higher in the Amerindian group than either in the Afro-Brazilian or White groups. Interestingly, a haplotype block between G590A<\/em> and A803G<\/em> was verified exclusively among Amerindians.<\/p>\n

Conclusions<\/strong><\/p>\n

Our results indicate that ethnic admixture might contribute to a particular pattern of genetic diversity in the NAT2<\/em> gene and also offer new insights for the investigation of possible new NAT2<\/em> gene-environment effects in admixed populations.<\/p>\n

Read the entire article here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Interethnic diversity of NAT2 polymorphisms in Brazilian admixed populations BMC Genetics Volume 11, Number 1 (2010-10-05) pages 87-93 DOI: 10.1186\/1471-2156-11-87 Jhimmy Talbot Laborat\u00f3rio de Farmacogen\u00f4mica e Epidemiologia Molecular Universidade Estadual de Santa Cruz Luiz Alexandre V. Magno Laborat\u00f3rio de Farmacogen\u00f4mica e Epidemiologia Molecular Universidade Estadual de Santa Cruz Cinthia VN Santana Laborat\u00f3rio de Farmacogen\u00f4mica e […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,83,21,2039,8],"tags":[9745,9738,9743,9742,9736,9737,9740,9744,9741,9739],"class_list":["post-20814","post","type-post","status-publish","format-standard","hentry","category-articles","category-brazil","category-latincarib","category-health-medicine","category-media-archive","tag-bmc-genetics","tag-cinthia-vn-santana","tag-fabricio-rios-santos","tag-giuliano-di-pietro","tag-jhimmy-talbot","tag-luiz-alexandre-v-magno","tag-paulo-rs-melo","tag-ronan-correa","tag-ronan-x-correa","tag-sandra-mb-sousa"],"_links":{"self":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/20814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20814"}],"version-history":[{"count":0,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/20814\/revisions"}],"wp:attachment":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}