{"id":25776,"date":"2013-03-23T20:09:15","date_gmt":"2013-03-23T20:09:15","guid":{"rendered":"http:\/\/www.mixedracestudies.org\/wordpress\/?p=25776"},"modified":"2015-07-22T20:56:24","modified_gmt":"2015-07-22T20:56:24","slug":"genetic-background-of-patients-from-a-university-medical-center-in-manhattan-implications-for-personalized-medicine","status":"publish","type":"post","link":"https:\/\/mixedracestudies.org\/wp\/?p=25776","title":{"rendered":"Genetic Background of Patients from a University Medical Center in Manhattan: Implications for Personalized Medicine"},"content":{"rendered":"

Genetic Background of Patients from a University Medical Center in Manhattan: Implications for Personalized Medicine<\/a><\/em><\/strong><\/p>\n

PLoS ONE: A peer-reviewed, open access journal<\/a>
\nVolume 6, Number 5 (2011-05-04)
\n11 pages
\nDOI: 10.1371\/journal.pone.0019166<\/a><\/p>\n

Bamidele O. Tayo<\/strong>
\nDepartment of Preventive Medicine and Epidemiology
\nLoyola University Chicago
\nStritch School of Medicine, Maywood, Illinois<\/em><\/p>\n

Marie Teil<\/strong>
\nCharles R. Bronfman Institute for Personalized Medicine
\nMount Sinai School of Medicine, New York, New York<\/em><\/p>\n

Liping Tong
\n<\/strong>Department of Preventive Medicine and Epidemiology
\nLoyola University Chicago
\nStritch School of Medicine, Maywood, Illinois<\/em><\/p>\n

Huaizhen Qin<\/strong>
\nDepartment of Biostatistics and Epidemiology
\nCase Western University, Cleveland, Ohio<\/em><\/p>\n

Gregory Khitrov<\/strong>
\nCharles R. Bronfman Institute for Personalized Medicine
\nMount Sinai School of Medicine, New York, New York<\/em><\/p>\n

Weijia Zhang
\n<\/strong>Charles R. Bronfman Institute for Personalized Medicine
\nMount Sinai School of Medicine, New York, New York<\/em><\/p>\n

Quinbin Song<\/strong>
\nCharles R. Bronfman Institute for Personalized Medicine
\nMount Sinai School of Medicine, New York, New York<\/em><\/p>\n

Omri Gottesman
\n<\/strong>Charles R. Bronfman Institute for Personalized Medicine
\nMount Sinai School of Medicine, New York, New York<\/em><\/p>\n

Xiaofeng Zhu<\/strong>
\nDepartment of Biostatistics and Epidemiology
\nCase Western University, Cleveland, Ohio<\/em><\/p>\n

Alexandre C. Pereira<\/strong>
\nUniversity of Sao Paulo Medical School, Sao Paulo, Brazil<\/em><\/p>\n

Richard S. Cooper
\n<\/strong>Department of Preventive Medicine and Epidemiology
\nLoyola University Chicago
\nStritch School of Medicine, Maywood, Illinois<\/em><\/p>\n

Erwin P. Bottinger
\n<\/strong>Charles R. Bronfman Institute for Personalized Medicine
\nMount Sinai School of Medicine, New York, New York<\/em><\/p>\n

Background<\/strong><\/p>\n

The rapid progress currently being made in genomic science has created interest in potential clinical applications; however, formal translational research has been limited thus far. Studies of population genetics have demonstrated substantial variation in allele frequencies<\/a> and haplotype<\/a> structure at loci of medical relevance and the genetic background of patient cohorts may often be complex.<\/p>\n

Methods and Findings<\/strong><\/p>\n

To describe the heterogeneity in an unselected clinical sample we used the Affymetrix<\/a> 6.0 gene array chip<\/a> to genotype self-identified European Americans (N = 326), African Americans (N = 324) and Hispanics (N = 327) from the medical practice of Mount Sinai Medical Center in Manhattan, NY<\/a>. Additional data from US minority groups and Brazil were used for external comparison. Substantial variation in ancestral origin was observed for both African Americans and Hispanics; data from the latter group overlapped with both Mexican Americans and Brazilians in the external data sets. A pooled analysis of the African Americans and Hispanics from NY demonstrated a broad continuum of ancestral origin making classification by race\/ethnicity uninformative.<\/strong> Selected loci harboring variants associated with medical traits and drug response confirmed substantial within- and between-group heterogeneity.<\/p>\n

Conclusion
\n<\/strong>
\nAs a consequence of these complementary levels of heterogeneity group labels offered no guidance at the individual level. These findings demonstrate the complexity involved in clinical translation of the results from genome-wide association studies and suggest that in the genomic era conventional racial\/ethnic labels are of little value.<\/strong><\/p>\n

Read the entire article here in HTML<\/a> or PDF<\/a> format.<\/p>\n","protected":false},"excerpt":{"rendered":"

Genetic Background of Patients from a University Medical Center in Manhattan: Implications for Personalized Medicine PLoS ONE: A peer-reviewed, open access journal Volume 6, Number 5 (2011-05-04) 11 pages DOI: 10.1371\/journal.pone.0019166 Bamidele O. Tayo Department of Preventive Medicine and Epidemiology Loyola University Chicago Stritch School of Medicine, Maywood, Illinois Marie Teil Charles R. Bronfman Institute […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,2039,8,20],"tags":[12310,12311,12301,14158,12313,12312,12305,12304,12303,12302,596,12308,11247,12307,8736,1257,12306,12309],"class_list":["post-25776","post","type-post","status-publish","format-standard","hentry","category-articles","category-health-medicine","category-media-archive","category-usa","tag-alexandre-c-pereira","tag-alexandre-pereira","tag-bamidele-o-tayo","tag-bamidele-tayo","tag-erwin-bottinger","tag-erwin-p-bottinger","tag-gregory-khitrov","tag-huaizhen-qin","tag-liping-tong","tag-marie-teil","tag-new-york-city","tag-omri-gottesman","tag-plos-one","tag-quinbin-song","tag-richard-cooper","tag-richard-s-cooper","tag-weijia-zhang","tag-xiaofeng-zhu"],"_links":{"self":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/25776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25776"}],"version-history":[{"count":1,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/25776\/revisions"}],"predecessor-version":[{"id":41873,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/25776\/revisions\/41873"}],"wp:attachment":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}