{"id":26087,"date":"2013-07-23T17:22:03","date_gmt":"2013-07-23T17:22:03","guid":{"rendered":"http:\/\/www.mixedracestudies.org\/wordpress\/?p=26087"},"modified":"2015-09-25T02:59:49","modified_gmt":"2015-09-25T02:59:49","slug":"fracture-risk-assessment-without-raceethnicity-information","status":"publish","type":"post","link":"https:\/\/mixedracestudies.org\/wp\/?p=26087","title":{"rendered":"Fracture Risk Assessment without Race\/Ethnicity Information"},"content":{"rendered":"

Fracture Risk Assessment without Race\/Ethnicity Information<\/a><\/em><\/strong><\/p>\n

The Journal of Clinical Endocrinology & Metabolism<\/a>
\nVolume 97, Number 10<\/a> (2012-10-01)
\npages 3593-3602
\nDOI: 10.1210\/jc.2012-1997<\/a><\/p>\n

Shinya Ishii<\/strong>
\n<\/a>Department of Geriatric Medicine (S.I.)
\nGraduate School of Medicine
\nUniversity of Tokyo<\/em><\/p>\n

Gail A. Greendale<\/strong>
\nDavid Geffen School of Medicine
\nUniversity of California, Los Angeles<\/em><\/p>\n

Jane A. Caule<\/strong>
\nGraduate School of Public Health
\nUniversity of Pittsburgh<\/em><\/p>\n

Carolyn J. Crandall<\/strong>
\nDavid Geffen School of Medicine
\nUniversity of California, Los Angeles<\/em><\/p>\n

Mei-Hua Huang
\n<\/strong>David Geffen School of Medicine
\nUniversity of California, Los Angeles<\/em><\/p>\n

Michelle E. Danielson
\n<\/strong>Graduate School of Public Health
\nUniversity of Pittsburgh<\/em><\/p>\n

Arun S. Karlamangla<\/strong>
\nDavid Geffen School of Medicine
\nUniversity of California, Los Angeles<\/em><\/p>\n

Context<\/strong>: Dual-energy x-ray absorptiometry<\/a>-derived bone mineral density<\/a> (BMD) does not explain interracial differences in fracture risk; thus, BMD-based fracture risk assessment requires patient race\/ethnicity information and ethnicity-specific BMD reference databases.<\/p>\n

Objective<\/strong>: The objective of the study was to investigate whether composite femoral neck strength indices, which integrate dual-energy x-ray absorptiometry-derived femoral neck size, femoral neck BMD, and body size, will allow fracture risk assessment without requiring race\/ethnicity information.<\/p>\n

Design<\/strong>: This was a prospective cohort study.<\/p>\n

Setting and Participants<\/strong>: A total of 1940 community-dwelling women aged 42\u201353 yr from four race\/ethnicity groups (968 Caucasian, 512 African-American, 239 Japanese, and 221 Chinese) were followed up for 9 yr.<\/p>\n

Outcome Measurements<\/strong>: Self-reported, nondigital, noncraniofacial fractures were measured.<\/p>\n

Results<\/strong>: Two hundred and two women (10.4%) sustained fractures and 82 (4.3%) had minimum-trauma fractures. Each sd increment in any of the strength indices was associated with a 34\u201341% reduction in fracture hazard over 9 yr (each P < 0.001). Race\/ethnicity predicted fracture hazard independent of BMD (P = 0.02) but did not predict fracture hazard independent of any of the composite indices (P = 0.11\u20130.22). Addition of race\/ethnicity did not improve risk discrimination ability of the strength indices, but did significantly improve the discrimination ability of BMD. The discrimination ability of BMD with race\/ethnicity was not statistically different from that of any of the strength indices without race\/ethnicity.<\/strong><\/p>\n

Conclusions<\/strong>: Composite strength indices of the <\/strong>femoral neck<\/strong><\/a> can predict fracture risk without race\/ethnicity information as accurately as bone mineral density does in combination with race\/ethnicity information and therefore would allow risk prediction in people of mixed race\/ethnicity and in groups without a BMD reference database.<\/strong><\/p>\n

Read or purchase the article here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Fracture Risk Assessment without Race\/Ethnicity Information The Journal of Clinical Endocrinology & Metabolism Volume 97, Number 10 (2012-10-01) pages 3593-3602 DOI: 10.1210\/jc.2012-1997 Shinya Ishii Department of Geriatric Medicine (S.I.) Graduate School of Medicine University of Tokyo Gail A. Greendale David Geffen School of Medicine University of California, Los Angeles Jane A. Caule Graduate School of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,2039,8,20],"tags":[12532,12537,12529,12535,12533,12527,12534,12528,12539,12530,12531,12536,12542,12526,12538],"class_list":["post-26087","post","type-post","status-publish","format-standard","hentry","category-articles","category-health-medicine","category-media-archive","category-usa","tag-arun-karlamangla","tag-arun-s-karlamangla","tag-carolyn-crandall","tag-carolyn-j-crandall","tag-gail-a-greendale","tag-gail-greendale","tag-jane-a-cauley","tag-jane-cauley","tag-journal-of-clinical-endocrinology-metabolism","tag-mei-hua-huang","tag-michelle-danielson","tag-michelle-e-danielson","tag-osteoporosis","tag-shinya-ishii","tag-the-journal-of-clinical-endocrinology-metabolism"],"_links":{"self":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/26087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26087"}],"version-history":[{"count":2,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/26087\/revisions"}],"predecessor-version":[{"id":42896,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/26087\/revisions\/42896"}],"wp:attachment":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}