{"id":36195,"date":"2014-04-05T19:48:07","date_gmt":"2014-04-05T19:48:07","guid":{"rendered":"http:\/\/www.mixedracestudies.org\/wordpress\/?p=36195"},"modified":"2014-04-05T19:49:07","modified_gmt":"2014-04-05T19:49:07","slug":"ancestry-informative-markers-clarify-the-regional-admixture-variation-in-the-costa-rican-population","status":"publish","type":"post","link":"https:\/\/mixedracestudies.org\/wp\/?p=36195","title":{"rendered":"Ancestry Informative Markers Clarify the Regional Admixture Variation in the Costa Rican Population"},"content":{"rendered":"<p><a href=\"http:\/\/muse.jhu.edu\/login?auth=0&amp;type=summary&amp;url=\/journals\/human_biology\/v085\/85.5.campos-sanchez.html\" target=\"_blank\"><em><strong>Ancestry Informative Markers Clarify the Regional Admixture Variation in the Costa Rican Population<\/strong><\/em><\/a><\/p>\n<p><a href=\"http:\/\/muse.jhu.edu\/journals\/human_biology\" target=\"_blank\">Human Biology<\/a><br \/>\n<a href=\"http:\/\/muse.jhu.edu\/journals\/human_biology\/toc\/hub.85.5.html\" target=\"_blank\">Volume 85, Number 5, October 2013<\/a><br \/>\npages 721-740<br \/>\nDOI: 10.1353\/hub.2013.0041<\/p>\n<p><a href=\"http:\/\/bio.psu.edu\/directory\/rxc327\" target=\"_blank\"><strong>Rebeca Campos-S\u00e1nchez<\/strong><\/a><br \/>\n<em>Universidad de Costa Rica, San Jos\u00e9, Costa Rica<\/em><\/p>\n<p><a href=\"http:\/\/www.researchgate.net\/profile\/Henriette_Raventos\/\" target=\"_blank\"><strong>Henriette Ravent\u00f3s<\/strong><\/a>, Associate Professor and Researcher<br \/>\n<em>Universidad de Costa Rica, San Jos\u00e9, Costa Rica<\/em><\/p>\n<p><a href=\"http:\/\/anc.cr\/miembros\/curriculum-vitae-ramiro-barrantes-mesen.html\" target=\"_blank\"><strong>Ramiro Barrantes<\/strong><\/a>, Professor of Biology<br \/>\n<em>Universidad de Costa Rica, San Jos\u00e9, Costa Rica<\/em><\/p>\n<p>The genetic structure of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Costa_Rica\" target=\"_blank\">Costa Rica\u2019s<\/a> population is complex, both by region and by individual, due to the admixture process that started during the 15th century and historical events thereafter. Previous studies have been done mostly on Amerindian populations and the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Costa_Rican_Central_Valley\" target=\"_blank\">Central Valley<\/a> inhabitants using various <a href=\"http:\/\/en.wikipedia.org\/wiki\/Microsatellite\" target=\"_blank\">microsatellites<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondrial_DNA\" target=\"_blank\">mitochondrial DNA<\/a> markers. Here, we study for the first time a random sample from all regions of the country with <a href=\"http:\/\/en.wikipedia.org\/wiki\/Ancestry-informative_marker\" target=\"_blank\">ancestry informative markers<\/a> (AIMs) to address the individual and regional admixture proportions. A sample of 160 male individuals was screened for 78 AIMs customized in a GoldenGate platform from <a href=\"http:\/\/en.wikipedia.org\/wiki\/Illumina_(company)\" target=\"_blank\">Illumina<\/a>. We observed that this small set of AIMs has the same power of hundreds of microsatellites and thousands of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Single-nucleotide_polymorphism\" target=\"_blank\">single-nucleotide polymorphisms<\/a> to evaluate admixture, with the benefit of reducing genotyping costs. This type of investigation is necessary to explore new genetic markers useful for forensic and genetic investigation. Our data showed a mean admixture proportion of 49.2% European (EUR), 37.8% Native American (NAM), and 12.9% African (AFR), with a disproportionate admixture composition by region. In addition, when Chinese (CHB) was included as a fourth component, the proportions changed to 45.6% EUR, 33.5% NAM, 11.7% AFR, and 9.2% CHB. The admixture trend is consistent among all regions (EUR &gt; NAM &gt; AFR), and individual admixture estimates vary broadly in each region. Though we did not find stratification in Costa Rica\u2019s population, gene admixture should be evaluated in future genetic studies of Costa Rica, especially for the Caribbean region, as it contains the largest proportion of African ancestry (30.9%).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ancestry Informative Markers Clarify the Regional Admixture Variation in the Costa Rican Population Human Biology Volume 85, Number 5, October 2013 pages 721-740 DOI: 10.1353\/hub.2013.0041 Rebeca Campos-S\u00e1nchez Universidad de Costa Rica, San Jos\u00e9, Costa Rica Henriette Ravent\u00f3s, Associate Professor and Researcher Universidad de Costa Rica, San Jos\u00e9, Costa Rica Ramiro Barrantes, Professor of Biology Universidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,21,2039,8],"tags":[8950,17188,6918,17189,17187],"class_list":["post-36195","post","type-post","status-publish","format-standard","hentry","category-articles","category-latincarib","category-health-medicine","category-media-archive","tag-costa-rica","tag-henriette-raventos","tag-human-biology","tag-ramiro-barrantes","tag-rebeca-campos-sanchez"],"_links":{"self":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/36195","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36195"}],"version-history":[{"count":0,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/36195\/revisions"}],"wp:attachment":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36195"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36195"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}