{"id":42628,"date":"2015-09-09T19:35:55","date_gmt":"2015-09-09T19:35:55","guid":{"rendered":"http:\/\/www.mixedracestudies.org\/?p=42628"},"modified":"2015-09-14T18:05:11","modified_gmt":"2015-09-14T18:05:11","slug":"characterizing-raceethnicity-and-genetic-ancestry-for-100000-subjects-in-the-genetic-epidemiology-research-on-adult-health-and-aging-gera-cohort","status":"publish","type":"post","link":"https:\/\/mixedracestudies.org\/wp\/?p=42628","title":{"rendered":"Characterizing Race\/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort"},"content":{"rendered":"

Characterizing Race\/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort<\/a><\/strong><\/em><\/p>\n

Genetics<\/a>
\nAugust 1, 2015, Volume 200, Number 4<\/a>
\npages 1285-1295
\nDOI: 10.1534\/genetics.115.178616<\/a><\/p>\n

Yambazi Banda<\/strong><\/a>
\nMark N. Kvale<\/strong>
\n Thomas J. Hoffmann<\/strong>
\n Stephanie E. Hesselson<\/strong>
\n Dilrini Ranatunga<\/strong>
\n Hua Tang<\/strong>
\n Chiara Sabatti<\/strong>
\n Lisa A. Croen<\/strong>
\n Brad P. Dispensa<\/strong>
\n Mary Henderson<\/strong>
\n Carlos Iribarren<\/strong>
\n Eric Jorgenson<\/strong>
\n Lawrence H. Kushi<\/strong>
\n Dana Ludwig<\/strong>
\n Diane Olberg<\/strong>
\n Charles P. Quesenberry Jr.<\/strong>
\n Sarah Rowell<\/strong>
\n Marianne Sadler<\/strong>
\n Lori C. Sakoda<\/strong>
\n Stanley Sciortino<\/strong>
\n Ling Shen<\/strong>
\n David Smethurst<\/strong>
\n Carol P. Somkin<\/strong>
\n Stephen K. Van Den Eeden<\/strong>
\n Lawrence Walter<\/strong>
\n Rachel A. Whitmer<\/strong>
\n Pui-Yan Kwok<\/strong>
\n Catherine Schaefer<\/strong>
\n Neil Risch<\/strong><\/p>\n

Using genome-wide genotypes, we characterized the genetic structure of 103,006 participants in the Kaiser Permanente Northern California <\/a>multi-ethnic Genetic Epidemiology Research on Adult Health and Aging<\/a> Cohort and analyzed the relationship to self-reported race\/ethnicity. Participants endorsed any of 23 race\/ethnicity\/nationality categories, which were collapsed into seven major race\/ethnicity groups. By self-report the cohort is 80.8% white and 19.2% minority; 93.8% endorsed a single race\/ethnicity group, while 6.2% endorsed two or more. Principal component<\/a> (PC) and admixture analyses were generally consistent with prior studies. Approximately 17% of subjects had genetic ancestry from more than one continent, and 12% were genetically admixed, considering only nonadjacent geographical origins. Self-reported whites were spread on a continuum along the first two PCs, indicating extensive mixing among European nationalities. Self-identified East Asian nationalities correlated with genetic clustering<\/a>, consistent with extensive endogamy<\/a>. Individuals of mixed East Asian\u2013European genetic ancestry were easily identified; we also observed a modest amount of European genetic ancestry in individuals self-identified as Filipinos. Self-reported African Americans and Latinos showed extensive European and African genetic ancestry, and Native American genetic ancestry for the latter. Among 3741 genetically identified parent\u2013child pairs, 93% were concordant for self-reported race\/ethnicity; among 2018 genetically identified full-sib pairs<\/a>, 96% were concordant; the lower rate for parent\u2013child pairs was largely due to intermarriage. The parent\u2013child pairs revealed a trend toward increasing exogamy<\/a> over time; the presence in the cohort of individuals endorsing multiple race\/ethnicity categories creates interesting challenges and future opportunities for genetic epidemiologic<\/a> studies.<\/p>\n

Read or purchase the article here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Characterizing Race\/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort Genetics August 1, 2015, Volume 200, Number 4 pages 1285-1295 DOI: 10.1534\/genetics.115.178616 Yambazi Banda Mark N. Kvale Thomas J. Hoffmann Stephanie E. Hesselson Dilrini Ranatunga Hua Tang Chiara Sabatti Lisa A. Croen Brad P. Dispensa […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,2039,8,20],"tags":[20979,455,4587,20992,20997,20985,20977,20983,20991,20984,20976,20981,20970,20969,3271,20971,20982,20994,20990,20978,20988,20987,20973,20980,3276,20996,20995,20986,20989,20975,20993,20974,20972],"class_list":["post-42628","post","type-post","status-publish","format-standard","hentry","category-articles","category-health-medicine","category-media-archive","category-usa","tag-brad-p-dispensa","tag-california","tag-carlos-iribarren","tag-carol-p-somkin","tag-catherine-schaefer","tag-charles-p-quesenberry-jr","tag-chiara-sabatti","tag-dana-ludwig","tag-david-smethurst","tag-diane-olberg","tag-dilrini-ranatunga","tag-eric-jorgenson","tag-genetic-epidemiology-research-on-adult-health-and-aging","tag-gera","tag-hua-tang","tag-kaiser-permanente","tag-lawrence-h-kushi","tag-lawrence-walter","tag-ling-shen","tag-lisa-a-croen","tag-lori-c-sakoda","tag-marianne-sadler","tag-mark-n-kvale","tag-mary-henderson","tag-neil-risch","tag-pui-yan-kwok","tag-rachel-a-whitmer","tag-sarah-rowell","tag-stanley-sciortino","tag-stephanie-e-hesselson","tag-stephen-k-van-den-eeden","tag-thomas-j-hoffmann","tag-yambazi-banda"],"_links":{"self":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/42628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=42628"}],"version-history":[{"count":2,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/42628\/revisions"}],"predecessor-version":[{"id":42724,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=\/wp\/v2\/posts\/42628\/revisions\/42724"}],"wp:attachment":[{"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=42628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=42628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mixedracestudies.org\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=42628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}