Mixed Race Studies

Ethnicity and Stroke: Beware of the Fallacies

Stroke
Volume 31, Issue 5 (May 2000)
pages 1013-1015
DOI: 10.1161/​01.STR.31.5.1013

Osvaldo Fustinoni, MD
Departments of Neurology
University of Buenos Aires, Buenos Aires, Argentina

José Biller, MD, Professor of Neurology and Neurological Surgery
Loyola University, Chicago

The role of ethnicity in stroke has been the subject of a considerable number of published reports. A quick Medline search detected 454 citations on “ethnicity and stroke,” 386 on “stroke in blacks,” 251 on “stroke in African Americans,” and 74 on “stroke in Hispanics,” of which only a few can be mentioned here. There even exists a journal dedicated to ethnicity and health.

However, the assumption that ethnicity is an isolated epidemiological variable delineating clinically distinct disease subgroups is controversial. The very concept of the word may be confounded with race (“black”), a common language or culture (“Hispanic”), a shared geographic origin (“Asian”), or a presumed common descent with diffuse boundaries (“Caucasian”). Ethnic categories are usually not defined in scientific reports, which results in dubious findings that are difficult to compare. The idea that a socially defined variable may reveal biological differences is fallacious, leading dangerously to biological determinism. For example, the genetic variation between races, traditionally classified on phenotype, is only slightly greater (10%) than that between nations (6%), and much larger within a local population (84%). Moreover, the genes responsible for skin color are few and are not associated with genetic markers for disease.

Ethnicity as a variable may be too greatly influenced by cultural attitude and therefore biased. In the past, this attitude led to the entire invention of diseases on the basis of race. At a time when the genetic inequality of races was considered obvious, the existence of these diseases was not questioned. In the present, ethnicity may be used euphemistically to avoid racist implications. A survey of 48 medical schools in the United States revealed that up to 91% of clerkship directors answered “yes” or “variable” after being queried whether students were taught by example to use the terms “black” or “white” when introducing case presentations. In another study, “black” patients were far more likely than “whites” to be racially identified at morning report. As recently as 1991, arterial hypertension has been related to skin color, even allowing for the fact that darker “blacks” may as a consequence be poorer and suffer more psychosocial stress.

Ethnic classification may vary from one community to another, as the perception of an ethnic group may be different across countries. As Caldwell and Popenoe put it, “what is black to someone from the United States may be white to a Brazilian or a Caribbean islander.” It may be added that the authors of the present editorial, both of European descent and born and raised in Spanish-speaking countries, would probably be classified as “Hispanic” in the US, although neither is of Spanish descent. Obviously, there is no such thing as a “Hispanic” ethnic group in Spain or Latin America.

Ethnicity is not a dichotomous variable, such as gender. How black is black? How is a person classified whose father is “white” and mother “black”? What about “mixed” grandparents? How does one classify a phenotypically “black” (by US standards) Spanish-speaking national from Central America? How are his children classified? Finally, how white is white? Do a Scot from Edinburgh and an Italian from Milan belong to the same ethnic group?…

…To avoid the shortcomings linked to classification, it has been proposed (and is now used in many reports) that patients entering population studies “self-classify” their ethnicity, assuming that “racial and ethnic categories are understood by the populations questioned.”

However, misinterpretation, confusion, and self-reclassification have been found in these cases. One striking example is that the category “South and Central American” was thought by respondents in one census to refer to natives of the south and central United States!…

…The consequences of flawed ethnicity research may lead to the assumption that ethnic minorities are an unhealthy social burden, that there are “ethnic” diseases which separate specific groups from the general population, that consequently they do not merit any further attention, and that “whites” are the “gold standard” of health. All this could do nothing but fuel racial prejudice…

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Against racial medicine

Patterns of Prejudice
Volume 40, Numbers 4
/5 (2006), Special Issue: Race and Contemporary Medicine
pages 481-493
DOI: 10.1080/00313220601020189

Joseph L. Graves Jr., Dean of University Studies; Professor of Biological Sciences
North Carolina Agricultural and Technical State University, Greensboro

Michael R. Rose, Director of the University of California Network for Experimental Research on Evolution; Professor of Biological Sciences
University of California, Irvine

Some scholars claim that recent studies of human genetic variation validate the existence of human biological races and falsify the idea that human races are socially constructed misconceptions. They assert that analyses of DNA polymorphisms unambiguously partition individuals into groups that are very similar to lay conceptions of race. Furthermore, they propose that this partitioning allows us to identify specific loci that can explain contemporary health disparities between the supposed human races. From this, it appears that racial medicine has risen again. In this essay Graves and Rose construct a case against racial medicine. Biological races in other species are strongly differentiated genetically. Because human populations do not have such strong genetic differentiation, they are not biological races. Nonetheless, the lack of population genetic knowledge among biomedical researchers has led to spuriously racialized human studies. But human populations are not genetically disjoint. Social dominance may lead to medical differences between socially constructed races. In order to resolve these issues, medicine should take both social environment and population genetics into account, instead of dubious ‘races’ that inappropriately conflate the two.

Racial medicine has risen again

Charles B. Davenport, one of the most respected scientists of the first decades of the twentieth century, argued that laziness was a hereditary trait. Davenport claimed in particular that laziness was a heredity character of Southern Whites. Later epidemiological studies determined that ‘white trash’ laziness was actually the result of heavy infections caused by the nematode necator americanus.  But, for Davenport and many other biologists of his time, the phenotypic differences displayed by particular populations were proof positive of the existence of human races. They believed that these races differed in readily observable features, such as skin colour and body proportions, and also in those they could not directly observe, such as intellect, morality, character, disease predisposition and resistance. In 1921, for example, Ernest Zimmerman published a report on differences in the manifestation of syphilis in Blacks and Whites. Such thinking helped to sanction the now infamous Tuskegee syphilis experiment.  Modern biologists recoil with horror when asked to revisit this sad episode in the history of science.

The rationale for the Tuskegee experiment was the underlying assumption that the Negro was genetically inferior to Whites. Thus, the perceived differences in incidence rates and progression of disease were thought to reside in characteristics intrinsic to the race, as opposed to the social conditions under which visibly darker-skinned persons of African descent lived in the United States. (It is significant that many ‘white Americans’ have African ancestors but ‘pass as white’, an anomaly to which we will return below.) Therefore, the Tuskegee experiment suffered not only from its moral shortcomings, but also from poor experimental design. The results of the experiment could not have distinguished between any genetically based difference in disease progression, since many environmental and social differences between African Americans and the Swedish cohorts with which they were to be compared were not properly controlled. With hindsight, the scientific problems of this experiment are obvious. What is not recognized is that modern discussions of race and medicine have not moved very far beyond the misconceptions that gave birth to the Tuskegee research programme...

…The identification of human races is not based on cogent biology

While humans have always recognized the existence of physical differences between groups, they haven’t always described those differences in racial terms. Racial theories of human differentiation were not a consistent theme of the ancient world, and really did not begin to flourish until after the European voyages of discovery in the fifteenth century. European naturalists of the eighteenth century were divided about the characterization of human differences. Almost all agreed that there was only one human species, yet they disagreed about whether there was a legitimate way to rank the various groups of humans hierarchically. For example, Carl Linneaus’s Systema Naturae (1735) classified human races partly on the basis of subjectively determined behavioural traits. It is not clear, however, what Linnaeus meant by the use of the term ‘race’. It seems that his classification scheme was describing subspecies of humans based on morphological features. According to it, European traits were clearly superior to others, and Africans were assigned the lowest rung in the hierarchy.

Such racist ideas were transplanted to America during colonial times, along with other biological absurdities. During American chattel slavery, the socially defined race of the offspring of slavemasters and slave women was ‘Negro’. Virginia law classified Eston Hemmings, who was 87.5 per cent European according to genetic ancestry, as ‘Negro’. Geneticists now suspect that Thomas Jefferson was his father, based on family genealogies and a genetic marker specific to the Jefferson family found in Eston’s descendants.

The one-drop rule (also called ‘hypo-descent’) in the United States differs from definitions of ‘blackness’ in Canada, Mexico, Britain and Brazil. Individuals, therefore, could move from one country to another and be classified differently according to the social custom. Indeed, in the United States, individuals have been born as a member of one race and died as a member of another. European ethnic groups, such as the Irish and Italians, did not become ‘white’ until the twentieth century. Such ‘races’ are clearly based on social conventions, as opposed to biological measures of genetic ancestry. Socially produced racial ideology from the very beginning influenced the collection and interpretation of data relating to human biological variation…

Read the entire article here.

Blood and stories: how genomics is rewriting race, medicine and human history

Patterns of Prejudice
Volume 40, Numbers 4
/5 (2006), Special Issue: Race and Contemporary Medicine
pages 303-333
DOI: 10.1080/00313220601020064

Priscilla Wald, Professor of English and Women’s Studies
Duke University

In 2003 Howard University announced its intention to create a databank of the DNA of African Americans, most of whom were patients in their medical centre. Proponents of the decision invoked the routine exclusion of African Americans from research that would give them access to the most up-to-date medical technologies and treatments. They argued that this databank would rectify such exclusions. Opponents argued that such a move tacitly affirmed the biological (genetic) basis of race that had long fuelled racism as well as that the potential costs were not worth the uncertain benefits. Howard University’s controversial decision emerges from research in genomic medicine that has added new urgency to the question of the relationship between science and racism. This relationship is the topic of Wald’s essay. Scientific disagreements over the relative usefulness of ‘race’ as a classification in genomic medical research have been obscured by charges of racism and political correctness. The question takes us to the assumptions of population genomics that inform the medical research, and Wald turns to the Human Genome Diversity Project, the new Genographics Project and the 2003 film Journey of Man to consider how racism typically inheres not in the intentions of researchers, but in the language, images and stories through which scientists, journalists and the public inevitably interpret information. Wald demonstrates the importance of understanding those stories as inseparable from scientific and medical research. Her central argument is that if we understand the power of the stories we can better understand the debates surrounding race and genomic medicine, which, in turn, can help us make better ethical and policy decisions and be useful in the practices of science and medicine.

To understand how genomic research can reproduce racism, it is necessary to understand how racism is articulated through that research as it is practised in the context of particular social formations. The articulation is produced through stories of race and genomic research, which take many forms as they make their way from the scientific community to the general public. Stories about the research reach public consciousness through such controversial decisions as the NHGC databank as well as through the discoveries and innovations emerging from the labs of pharmaceutical companies, universities and federal institutions. Accounts of genomic research offer exciting promises, ranging from new explanations (and treatments) for some of the most feared medical problems, from cancer to avian flu, to new ways of understanding (and managing) human behaviour. They also capture the public imagination with claims of new discoveries that offer insight into the mysteries of human origins and human history, and the genealogies of individuals as well as groups. The claims and promises fuse in the stories of genomic research broadcast in the mainstream media, and they in turn influence policy and funding decisions and help to shape future research. These stories are fundamental in the production of scientific and medical knowledge and, therefore, as I argue in what follows, attention to them needs to be incorporated into scientific and medical research.

…Genomic information is notoriously difficult to interpret even by researchers in the field. The frequency of alleles that mark genetic drift—the the rate of genetic changes resulting from mutations, or divergent alleles, in relatively inbred populations—tells where and when there was a divergence within a group. Those alleles are used to mark ancestry. But, as Michael J. Bamshad and Steve E. Olson note, ‘how groups are divided depends on which genes are examined; simplistically put, you might fit into one group based on your skin-color genes but another based on a different characteristic’.  The DNA that yields information about one’s ancestry—typically mitochondrial and Y-chromosome DNA—in fact tells only part of the story of genetic ancestry. The complexity of nuclear DNA does not yield sufficiently clear information to complete it. Moreover, as Jay Kaufman has pointed out, Risch et al. ’s study relies on the dismissal of ‘intermediate groups’, such as ‘Hispanic Americans’, whom Risch et al. acknowledge could ‘aggregate genetically with Caucasians, Native Americans, African Americans or form their own cluster’ and are therefore ‘not easily classified’, but the size of those groups attenuates their claims. They are too large to be dismissed as an exception. Intermixture is increasingly the rule…

…Pointing an accusatory finger at ‘political correctness’ not only deflects the scientific dispute, but also ignores the medical importance of the social consequences of racism, measured in health outcomes. Drawing a stark contrast between medical science and social concerns, a distinction that Risch et al. ’s article itself troubles, that accusation renders social concerns suspect except as they provide epidemiologically useful information. Neither Wade nor Risch et al . address what constitutes epidemiologically useful information. Risch et al. dismiss potential abuses of genomic information (such as those that fuel racism) as unscientific, arguing

that identifying genetic differences between races and ethnic groups, be they for random genetic markers, genes that lead to disease susceptibility or variation in drug response, is scientifically appropriate. What is not scientific is a value system attached to any such findings.

But this assertion presumes that science and medicine can be divorced from their social contexts and that information circulates in value-neutral terms. History does not support that presumption, and calling racism ‘not scientific’ does not address the value system or alleviate the problems—including health outcomes—associated with it…

…Taking racism into account does not mean refusing to collect and classify data in medical research according to race and ethnicity. On the contrary, those classifications provide important epidemiological information, as Risch et al. maintain, about the impact of social and environmental factors—including socio-economic inequities and cultural biases—on the health of individuals and groups. As Troy Duster argues, the way to ‘recognize, engage, and clarify the complexity of the interaction between any taxonomies of race and biological, neurophysiological, society, and health outcomes’ is to consider ‘how science studies deploy the concept of race’. The story of how biotechnology is revolutionizing medicine has put genomic research very much into public consciousness and has made genetic explanations of health disparities among individuals and especially groups the ‘default position’. Distinguishing between genomic and social and environmental factors in disease susceptibility and drug response is notoriously difficult, especially since, as Keita et al. note, ‘some environmental influences can be so subtle and occur so early in life as to be missed . . . ’. Yet, that distinction determines how researchers and practitioners understand and address the problem of health disparities. ‘Race’ and ‘ethnicity’ are very different as surrogates for genomics and for social and environmental factors in the assessment of health outcomes, which is why the larger stories in which the research is embedded are scientifically and medically as well as socially relevant…

Read the entire article here.

Finding a Match, and a Mission: Helping Blacks Survive Cancer

The New York Times
2012-05-11

Donald G. McNeil, Jr.

A month after his 2009 graduation from Yale Law School, Seun Adebiyi learned he had not one but two lethal blood cancers and began an odyssey to find a bone-marrow donor. Mr. Adebiyi, 28, who came to this country from Nigeria as a child, made appeals through Yale, on radio stations, in a YouTube video and even on a trip to Nigeria to ask law students to volunteer.

But finally, his doctor called, saying that a Nigerian woman in this country had donated her baby’s umbilical cord blood to a “cord-blood bank” and that the stem cells in it were a close enough match. After his own marrow — the source of his cancers — was wiped out, those cells were infused into him at Memorial Sloan Kettering Cancer Center. He has been in remission since.

Now he is trying to repay that debt, with an effort that experts say may save the lives of both Nigerians and black Americans. In February, he helped start Nigeria’s national bone-marrow registry, the first in Africa outside South Africa. He is now raising money to start a cord-blood bank there…

…But for African-Americans like Mr. Adebiyi, finding matches is particularly difficult. Blacks are less likely to register as donors; while blacks are 12.6 percent of the population, only 8 percent of registered donors are black.

“It’s lack of education about it, and mistrust of the medical system after scandals like Tuskegee,” said Shauna Melius, co-founder of Preserve Our Legacy, citing the Tuskegee, Ala., experiment in which government doctors recruited black farmers for research and let those with syphilis go untreated for decades. Her organization recruits donors at Harlem Hospital and through drives featuring black celebrities.

“Plus,” she added, “people are skeptical because you’re collecting DNA.”

Complicating the problem, blacks are more genetically diverse than whites. Anatomically modern Homo sapiens existed in Africa for 200,000 years before migrating north to Europe a little over 40,000 years ago, so all Europeans descend from the shallower end of the gene pool…

…It will particularly help those with more African genes. Most black Americans have some white ancestors and, on average, 35 percent European genes, but individuals vary widely…

Read the entire article here.

The fallacy of racial pharmacogenomics

Brazilian Journal of Medical and Biological Research
Volume 44, Number 4 (April 2011)
pages 268-275
DOI: 10.1590/S0100-879X2011007500031

S. D. J. Pena
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais
Belo Horizonte, MG, Brasil
GENE – Núcleo de Genética Médica, Belo Horizonte, MG, Brasil

Personalized pharmacogenomics aims to use individual genotypes to direct medical treatment. Unfortunately, the loci relevant for the pharmacokinetics and especially the pharmacodynamics of most drugs are still unknown. Moreover, we still do not understand the role that individual genotypes play in modulating the pathogenesis, the clinical course and the susceptibility to drugs of human diseases which, although appearing homogeneous on the surface, may vary from patient to patient. To try to deal with this situation, it has been proposed to use interpopulational variability as a reference for drug development and prescription, leading to the development of “race-targeted drugs”. Given the present limitations of genomic knowledge and of the tools needed to fully implement it today, some investigators have proposed to use racial criteria as a palliative measure until personalized pharmacogenomics is fully developed. This was the rationale for the FDA approval of BiDil for treatment of heart failure in African Americans. I will evaluate the efficacy and safety of racial pharmacogenomics here and conclude that it fails on both counts. Next I shall review the perspectives and the predicted rate of development of clinical genomic studies. The conclusion is that “next-generation” genomic sequencing is advancing at a tremendous rate and that true personalized pharmacogenomics, based on individual genotyping, should soon become a clinical reality.

Introduction

The American astrophysicist Neil deGrasse Tyson defined the “perimeter of ignorance” as the boundary where scientists face a choice: continue the quest for knowledge or invoke a deity or other supernatural forces. He used as an example no less than Isaac Newton himself, whose law of gravity enabled calculation of the force of attraction between any two objects. When computing the orbits of the planets around the sun, Newton feared that the mutual attraction between them would render the solar system unstable. He then concluded that God occasionally stepped in to make things right. A century later, the French astronomer Pierre-Simon de Laplace created a new mathematical tool called perturbation theory and used it to demonstrate that the solar system is in fact stable over periods of time much longer than Newton could predict. Laplacian science, therefore, no longer needed to postulate the interference of supernatural forces to explain astronomical facts.

Newton’s appeal to God, however unnecessary, may at first sight appear as a humble attitude of a great man. However, Tyson demonstrates that, on the contrary, it represented presumptuousness on his part: if his mathematics was not good enough to explain the phenomenon, then the problem was too complicated for any other human mind to figure out, then or anytime in the future. By “embracing ignorance” Newton’s attitude negatively infused a temporary stage of incomplete knowledge with a false permanency, running counter to the philosophy of open-mindedness and discovery that characterizes Science.

Pharmacogenetics and pharmacogenomics are likewise in a dilemma right at the edge of the perimeter of ignorance…

…To try to deal with this situation it has been proposed to use interpopulational variability as a reference for drug development and prescription, leading to the development of “race-targeted drugs”, as exemplified by the case of BiDil for treatment of heart failure in African Americans. The rationale for such strategy is that, since we still lack the pharmacogenomic knowledge necessary to implement true personalized treatment, we make do by using the race or the ethnic-geographic affiliation of a given patient as the replacement of the germane individual genotyping at critical loci.

Therein lies the fallacy of racial pharmacogenomics – being predicated on the idea that individual genotyping will be impossible to achieve in the near future, it “embraces ignorance”. Moreover, it often does so under false premises. For instance, in the FDA news release entitled “FDA Approves BiDil Heart Failure Drug for Black Patients” it is stated that this represents “a step toward the promise of personalized medicine”. But racial medicine is group medicine – most definitely it is not personalized medicine…

…I propose that, rather than thinking about populations, ethnicities or races, we should focus on the unique genome of a particular individual, which is structured as a mosaic of polymorphic haplotypes with diverse genealogical histories. This shifts the emphasis from populations to persons. We should strive to see each individual as having a singular genome and a unique life history, rather than try to impose on him/her characteristics of a group or population. Under this model, ideas such as that of human races or “race-targeted drugs” become meaningless and vanish like smoke.

The safety of racial pharmacogenomics

The adoption of racial pharmacogenomics by the FDA has serious implications that extend much beyond the restricted limits of the medical arena. Thus, it has to be evaluated not only scientifically, but also within a historical, sociological and philosophical context.

In the past, the belief that human races had substantial and clearly delimited biological differences contributed to justify discrimination and was used to oppress and foment injustices, even within the medical context. The concept of race is still loaded with ideology and carries within it relationships of power and domination. It is similar to a banana peel: empty, slippery and dangerous.

Thus, our final conclusion is that racial pharmaco-genomics fails on grounds of insufficient benefit/cost ratio: it has much to recommend against it and very little scientific justification in its favor.

To use racial pharmacogenomics as a palliative measure is tantamount to “embracing ignorance”. It erroneously confers persistence and credence to the idea that human races do exist. As pointed out by the sociologist Paul Gilroy, such persistence is toxic, contaminating and weakens all society…

Read the entire article here.

Why genes don’t count (for racial differences in health)

American Journal of Public Health
Volume 90, Number 11 (November 2000)
pages 1699-1702
DOI: 10.2105/AJPH.90.11.1699

Alan H. Goodman, Professor of Biological Anthropology
Hampshire College, Amherst, Massachusetts

There is a paradoxical relationship between “race” and genetics. Whereas genetic data were first used to prove the validity of race, since the early 1970s they have been used to illustrate the invalidity of biological races. Indeed, race does not account for human genetic variation, which is continuous, complexly structured, constantly changing, and predominantly within “races.” Despite the disproof of race-as-biology, genetic variation continues to be used to explain racial differences. Such explanations require the acceptance of 2 disproved assumptions: that genetic variation explains variation in disease and that genetic variation explains racial variation in disease. While the former is a form of geneticization, the notion that genes are the primary determinants of biology and behavior, the latter represents a form of racialization, an exaggeration of the salience of race. Using race as a proxy for genetic differences limits understandings of the complex interactions among political-economic processes, lived experiences, and human biologies. By moving beyond studies of racialized genetics, we can clarify the processes by which varied and interwoven forms of racialization and racism affect individuals “under the skin.”

…Professor Armelagos hinted at a powerful lesson: that scientific ideas can endure and be made to seem real if they have social and political–economic utility. An evolutionary framework that explained human variation had been established for more than a century, ever since the publication of Darwin’s Origin of Species. In the 1940s, Montagu used the “new evolutionary synthesis” to explain clearly why race was a biological myth. Yet the idea of race as biology persists today in science and society.

I was aware of the power of race as a worldview in 1973. But what I understood less was the idea’s ability to persist after it had been proven unscientific. If I had been asked in the 1970s whether race would survive as a way to think about human biological variation in 2000, I would have answered emphatically, “No!” I was naive to the durability of an economically useful idea.

Acceptance of the notion of race-as-biology declined in anthropology throughout the late 1970s and early 1980s. Yet, during the past decade, racialized notions of biology have made a comeback. This is especially true in human genetics, a field that, paradoxically, once drove the last nail into the coffin of race-as biology. In this commentary, I explain why race should not be used as a proxy for genetic or biological variation. I then explain and illustrate the unfounded assumptions that are needed for an acceptance that racial differences in disease are due to genetic differences among races…

…The Double Error Inherent in Genetic Explanations of Racial Differences

Two errors—2 leaps of illogic—are necessary for acceptance of the idea that racial differences in disease are due to genetic differences among races. The first leap is a form of geneticization, the belief that most biology and behavior are located “in the genes.”

Genes, of course, are often a part of the complex web of disease causality, but they are almost always a minor, unstable, and insufficient cause. The presence of Gm allotype, for example, might correlate to increased rates of diabetes in Native Americans, but the causal link is unknown. In other cases, the gene is not expressed without some environmental context, and it may interact with environments and other genes in nonadditive and unpredictable ways.

The second necessary leap of illogic is a form of scientific racialism, the belief that races are real and useful constructs. Importantly, this leap propels one from explaining disease variation as caused by genetic variation to explaining that racial differences in disease are caused by genetic variation among races.To accept this logic, one needs to also accept that genetic variation occurs along racial divides: that is, most variation occurs among races. However, we know from Lewontin’s work that this assumption is false for simple genetic systems. For a disease of complex etiology, genetics is an illogical explanation for racial differences.

Read the entire article here.

Breaking the Bonds of Race and Genomics

GeneWatch
Volume 25, Issue 1 (January-February, 2012): Genetics in 20 Years

Dorothy Roberts, George A. Weiss University Professor of Law and Sociology; Raymond Pace and Sadie Tanner Mossell Alexander Professor of Civil Rights
University of Pennsylvania

Twenty years ago it appeared that mainstream science finally was abandoning the concept of biological human races. From 18th century typologists to 20th century eugenicists, scientists have always been instrumental in justifying the myth that the human species is naturally divided by race. But the rejection of eugenics after World War II and discoveries by human evolutionary biologists in subsequent decades brought hope that a new science of human genetic diversity would replace the old racial science. In 2000, the Human Genome Project, which mapped the entire human genetic code, confirmed the genetic unity of the human species and the futility of identifying discrete racial groups in the remaining genetic difference. Biologically, there is only one human race. Race applied to human beings is a social grouping; it is a system originally devised in the 1700s to support slavery and colonialism that classifies people into a social hierarchy based on invented biological, cultural, and legal demarcations.

But instead of hammering the last nail in the coffin of an obsolete system, the science that emerged from sequencing the human genome has been shaped by a resurgence of interest in race-based genetic variation. Some scientists claim that clusters of genetic similarity detected with novel genomic theories and computer technologies correspond to antiquated racial classifications and prove that human racial differences are real and significant. Others are searching for genetic differences between races that could explain staggering inequalities in health and disease as well as variations in drug response, with the biotechnology and pharmaceutical industries poised to convert the new racial science into race-specific products. As we wait for the promise of gene-tailored medicine to materialize, race has become an avenue for turning the vision of tomorrow’s personalized medicines into today’s profit making commodities. While uncritically importing antiquated racial categories into research, the emerging racial science has a new twist—it claims to measure biological distinctions across races and “admixed” populations with more accurate precision, and without social bias…

Read the entire article here.

A race-based detour to personalized medicine

Canadian Medical Association Journal
Volume 184, Number 7 (2012-03-12)
DOI: 10.1503/cmaj.109-4133

Roger Collier, News Staff

Few experts in medical genetics would argue that June 23, 2005 wasn’t an important day. Consensus on whether it was a good or bad day is another matter. Some claim a major step on the long road to personalized medical care was taken. Others are far less convinced, suggesting it was the day the United States government decided, unwisely, to push the field of medical genetics into the heated realm of racial politics.

On that date, the US Food and Drug Administration (FDA) approved, for the first time, a drug for a specific race, to wit, the fixed-dose combination drug isosorbide dinitrate and hydralazine (BiDil) for use as a heart disease medication within the black population, who have a much higher risk of heart failure than whites…

…The licensing of isosorbide dinitrate/hydralazine thus became a turning point in discussions on the merits of race-based medicine, a debate that continues to rage. Critics of race-specific therapies argue that focusing on genetics rather than on social and economic inequalities will not reduce disparities in health outcomes and access to care among different ethnic groups. Furthermore, they say, race is a social, rather than a biological, construct.

“Using race is a bad proxy for genetic ancestry,” says Althea Grant, chief of the Epidemiology and Surveillance Branch, Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, at the US Centers for Disease Control and Prevention.

This opinion is shared by one of the world’s most famous geneticists: Craig Venter, the genetics pioneer who led the team that first sequenced the human genome in 2001. He has referred to the use of race and ethnicity in medical genetics as a crude tool and a personal pet peeve, suggesting that it will no longer be necessary once the price of sequencing genomes falls to an amount that would make it reasonable to sequence everybody’s genome, a figure he pegged at US$1000…

…The first problem with using race in medical genetics is determining which races constitute a part of someone’s background. Few people have extensive knowledge of their ancestral lineage, and skin colour and other external markers don’t tell the full story. Even people who are aware of their mixed heritage often place themselves in one camp — or are put there by others. Prominent examples include US President Barack Obama and professional golfer Tiger Woods, who are often referred to as black even though the former has a white mother and the latter’s mother hails from Thailand.

“People tend to self-identify with a particular race more than another even if there is a mix,” says Grant. “They might not even know all the ancestries that are in the mix.”

In some areas of medicine, using race as a screening tool has already been shown to create problems, both practical and ethical. That’s why states abandoned the practice of screening only black newborns for hemoglobinopathies, such as sickle cell disease, Grant and colleagues concluded (Ethn Health 2011;16:377–88). The state of Georgia, the last holdout for ethnicity-based newborn screening, discontinued its use in 1998…

“If we go back to its origins, we find that BiDil did not begin as an ethnic drug. Rather it became ethnic over time and through a complex array of legal, commercial, and medical interventions, that transformed the drug’s identity,” wrote Jonathan Kahn, a law professor at Hamline University in Saint Paul, Minnesota (www.councilforresponsiblegenetics.org/pageDocuments/PLMVM6FTAO.pdf). Unlike “racialized medicine, which treats race as genetic, the use of race in medical practice has many legitimate and important places. Collecting broad-based epidemiological data is perhaps foremost among these. Only by using social categories of race is it possible to identify and track racial disparities in health, health care access and outcomes.”

Read the entire article here.

A 30 Percent of Mixed Race Component in Argentina’s Population

Agentina Investiga: Divulgación y Noticas Universitarias
Universidad Maimónides
Facultad de Ciencias Médicas
2012-04-09

Adrián Giacchino
Departamento de Prensa
Universidad Maimónides

The research of a team formed by anthropologists, biologists, biochemists and archeologists proves that the autochthonous contribution in Argentina’s population might be of a 30%. The results of the work, emerged from an analysis of blood donors in diverse regions of our country, indicate that there is a 65% of European component, a 30% Amerindian and a 5% African. Amerindian lineage is mainly maternal, decreases as we come close to the city of Buenos Aires and increases towards the north and the south.

How many times we have heard that in Argentina “we come from the ships…” and that we are “a melting pot”. This is believed by many people and it was written many times and even legitimated as valid knowledge. But, do we really come from the ships and are we a real melting pot?

“What exists is the mythology that we are white and European –indicates to InfoUniversidades Dr. Francisco Raúl Carnese, who is in charge of the laboratory of Biological Anthropology of the University-. However, our population is mixed. The native composition is very striking, especially in maternal ancestry, which increases towards the north and the south and it is also very important in the metropolitan area of Buenos Aires, particularly in the suburbs. We have the need to “bleach” populations, but the concept of “melting pot” is questioned. The populations’ genetics showed that there is no continuity between human populations, that the biological variations are of continuous nature. Races do not reflect biological reality, but are social constructions…

Read the entire article here.

Cultural Inversion and the One-Drop Rule: An Essay on Biology, Racial Classification, and the Rhetoric of Racial Transcendence

Albany Law Review
Volume 72, Issue 4 (2009)
Pages 909-928

Deborah W. Post, Professor Emeritus of Law
Touro College, Jacob D. Fuchsberg School of Law
Central Islip, New York

The great paradox in contemporary race politics is exemplified in the narrative constructed by and about President Barack Obama. This narrative is all about race even as it makes various claims about the diminished significance of race: the prospect of racial healing, the ability of a new generation of Americans to transcend race or to choose their own identity, and the emergence of a postracial society. While I do not subscribe to the post-racial theories that have been floated in the press and other media, I do believe that something of great cultural significance occurred which made the candidacy and the election of Barack Obama possible. This essay is an attempt on my part to consider what that change might have been by examining the relationship between science and social change, language and cultural categories, and the role law has played, if any, in dismantling the structures of racism.

What I have to say has very little to do with biology, except to the extent that racial classification is a cultural practice that sometimes deploys biological arguments strategically. Early in the Twentieth century sociologists and anthropologists noted that in the United States, race was more a matter of caste than class and that, unlike other caste systems, it is not cultural, but “biological.” In a racial caste, one sociologist argued, “the criterion is primarily physiognomic, usually chromatic, with socio-economic differences implied.”  Another noted that “American caste is pinned not to cultural but to biological features—to color, features, hair form, and the like.” Biology was used in this early sociological literature on race in a way that made it synonymous with physical appearance or physical characteristics. In politics and legal discourse at the time, racial purity was about “blood” and rules of descent…

…In this article, my thesis is simple. If racial caste has been upended by changes in legal rules that created a hierarchical racial structure, its demise also has been hastened by the use of symbols, a strategy of cultural inversion with respect to the meaning of race.  The operative terms of a centuries-old debate have been inverted. Instead of policing racial purity with arguments about blood and biology or the modern version of them, DNA and genes, these instruments of exclusion, the tools of white supremacists and segregationists, have been used effectively, most recently by Barack Obama, to demonstrate the physical connection between groups that are still treated discursively, politically and socially, as racially distinct…

…The movement to escape the one-drop rule, the rule that examines blood lines as far back as five generations or more, if that is what the multiracial movement is all about, is not, as far as I know, a movement that began in the black community. A major proponent is a white woman, Susan Graham, founder of “Project RACE,” which is the acronym for Reclassify All Children Equally.  What Susan Graham demands is that the children of parents who come from different races be acknowledged as the product of both groups. In other words, this white mother of a child or children whose father is a black man demands that the public, the discourse, the political  instrumentalities, the private institutions, acknowledge the status of her child as white as well as black…

…The demand for multiracial identity for the children of interracial marriage, however, may be explained in terms of a desire for status as long as we live in a society in which there is still a clear racial hierarchy. The demand that multiracial children be recognized as partly white did not come from blacks.  Nor is it surprising that Susan Graham, a major advocate for the multiracial category on the United States Census found an ally in Newt Gingrich, who opined that such a category might “‘be an important step toward transcending racial division.’” The enthusiasm for such alternative classifications leads skeptics to believe that this system of reclassification and the rhetoric of transcendence will make it easy to ignore the reality and the structure of racism.

It may be that the promotion of a multiracial identity provides some white parents with the assurance that they have not been rejected by their own children. Their children are part of them and, therefore, partly white. People who cross racial lines to marry do not leave behind all of their attitudes towards race; their internalized assumptions about racial characteristics and racial hierarchy can be a source of misunderstanding, a vulnerability that at the very worst can injure or divide family members…

Read the entire article here.