Mixed Race Studies

Sequencing the Trellis: The Production of Race in the New Human Genomics

Brown University
December 2003
185 pages

Brady Dunklee, Executive Director
ATRAVES US

In partial completion of the requirements for honors.

Note on the Title: “Trellis” refers to an analogy that NHGRI director Francis Collins uses to describe race and human evolution, emphasizing mixture between “races,” in opposition to evolutionary trees which emphasize divergence. “Sequencing” refers to the main activity of recent genomic research, and is meant to suggest both this activity and the differentiation of groups of people, which is the subject of this thesis.

Human genomic science has emerged in the past decade as a powerful new biological field, combining molecular and population genetics with advanced information technologies, allowing DNA sequencing and analysis in a rapid, high throughput fashion. In addition to producing a vast quantity of scientific data, the Human Genome Project and other efforts in human genomics have produced claims about the social implications of their work. The result has been a complex expert discourse on the nature of the human.

A particularly rich subset of this discourse has addressed the meanings, use and reality of race and ethnicity in light of new genomic knowledge. A great variety of positions on racial and ethnic difference have been put forth, best known of which is the contention that race is biologically meaningless.

This thesis shows that this claim is not the whole story. Genomic discourse has, since its beginnings, deployed and produced race in a constant, if variegated manner. A “technology of difference” has been produced, a set of terms, meanings, and ways in which knowledge is structured and authorized, whose collective action is to differentiate people racially and ethnically.

This thesis examines this technology of difference, showing that genomics is in fact making race, and demonstrating some of the ways in which it does so. My approach is an analysis of discourse, which addresses terminology, formal configurations and epistemology in the literatures produced by genomic scientists. The dominant characteristic in this discourse is instability. Meanings, forms, and claims shift and change on a variety of levels.

This thesis shows that surprising patterns can be seen in this instability, and that instability is itself a constitutive factor giving strength and cohesion to the genomic production of human racial and ethnic difference.

I suggest, further, that now is a crucial time for interventions to be made in the genomics of human difference. Those who want an end to race, or who want positive, livable transformations of race, can find both opportunity and danger in these new differentiations.

Table of Contents

• Title Page
• Dedication
• Acknowledgements
• Table of Contents
• Table of Figures
• Inscriptions
• Thesis Statement…………………………………………………………………
• Introduction……………………………………………………………………………
  • I. Unifications
  • II. Divisions
  • III. Contexts
  • IV. Materials and Methods
• Chapter 1: Categories and Keywords in the Genomics of Race
  • I. Transferals
  • II. “Race” and “Ethnicity”
  • III. Populations, Groups and Communities
  • IV. “Minorities” and “Inclusion”
  • VI. Chapter Summary
• Chapter 2: Formal Configurations: Nested Proxies & Perspectival Phasing
  • I. Theoretical Framework
  • II. Making Difference Within Race
  • III. Making Difference Around Race
• Chapter 3: Instability and Discourse
  • I. Reading and Writing
  • II. Articulate Instability
• Chapter 4: Epistemology……………………………………………………………
  • I. Definitions and Methods
  • II. One Drop
  • III. White Normativity
  • IV. Racial Essentialism
  • V. Three Spaces
• Conclusion…………………………………………………………………………
• Bibliography

Table of Figures

• Figure I-1— Craig Venter of Celera Genomics, left, shakes hands with Francis Collins of NHGRI, right, at a ceremony at the White House, June 2000.
• Figure I-2 — Cover of Nature, February 15, 2001. The mosaic includes the faces of Mendel, Watson and the Beatles.
• Figure I-3 — Stills from “Exploring Our Molecular Selves,” a film produced by NHGRI as part of a free educational toolkit for high school students.
• Figure 1-1 — “Populations” and Race: “Not everyone’s smiling. A plan to study haplotypes in these populations is prompting angry words.”
• Figure 2-1 — Diagram of racial schema in Risch, et al. (2002).
• Figure 2-2 — Perspectival Differentiation in Collins (2003).
• Figure 4-1 — One Drop Rule and Founding Populations in genomics.

…At first glance, the appearance of these types of anti-race critiques appears to frustrate an attempt to theorize a mainstream of genomic ideas about race and ethnicity—they simply appear contradictory. It is my contention that they are contradictory on significant levels, but that they share a terminology, a set of discursive patterns, and a certain epistemology that allow them to resolve such contradictions, and unite them in making race.

Even when the term race is used as a “misconception,” race is configured in new ways with respect to genomic knowledge. Race is produced, as an entity that is purely mythical and controverted by this expert discourse. Race is made by genomicists into something new which is not genomic…

Read the entire thesis here.