Breast cancer and racialized medicine

Posted in Articles, Health/Medicine/Genetics, Media Archive, United States on 2015-04-16 22:17Z by Steven

Breast cancer and racialized medicine

Race, Racism & Human Genetics IDS 243: Race, Racism, and Human Genetics
Willamette University
Salem, Oregon
2014-11-28

Stephanie Matsuura

Katie Herr

Camille Debreczeny

Race, Racism & Human Genetics IDS 243: Race, Racism, and Human Genetics is an interdisciplinary course taught at Willamette University by Emily Drew and Chris Smith. This blog represents the work of students enrolled in the course, and their reactions to current scholarly and popular work relating to the biology of human difference.

Racial disparities in breast cancer are often attributed to biology uncritically, without considering social factors. In many genetic studies, rhetorical framing of human diversity conflates differences between populations with racial categories. An unconscious complicity in the racial worldview informs these studies, which are then used to justify racialized explanations for disparities in breast cancer. Many researchers recognize that individualized, complete genome analysis would provide better care for patients, but lack the technological and economic resources to make this a realistic goal. Instead they rely on racialized medicine, which has serious consequences for women of color with breast cancer.

Racialized medicine occurs when the U.S. racial worldview goes unchallenged in the way it shapes medical research, health care practices, and public health policy. It is a way of making inequalities in health and illness seem natural by erroneously linking them to “innate” and “biological” differences between racial groups. In the U.S., women of color are disproportionately affected by breast cancer. Black women in particular have higher breast cancer mortality rates than any other racial/ethnic group in the country (Happe 2006). In this blog we aim to cover the main possible explanations for observed racial disparities in both incidence and prognosis of breast cancer. Studies have attributed racial disparities in both incidence and prognosis to the genetics underlying breast cancer as well as to social factors…

Read the entire article here.

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IDS 243 Race, Racism, & Human Genetics

Posted in Course Offerings, Health/Medicine/Genetics, Media Archive, Social Science, United States on 2015-04-16 21:15Z by Steven

IDS 243 Race, Racism, & Human Genetics

Willamette University
Salem, Oregon
Fall 2014

What accounts for human difference, and what does the biology of human variation tell us about race and the “life changes” of racial groups in contemporary society? This course examines the relationship between genes, geography, skin color and what we have come to understand as “race.” It will focus upon patterns of human genetic variation and consider how the completion of the Human Genome Project and the increasing availability of genomic data have changes our understanding of human population genetics. It will also address the historical role of science in taking the socially-constructed concept of race and turning it into scientific “fact,” and explore how this past history both shapes and constrains contemporary research in the biology of human diversity. The course will consider contemporary case studies in which race becomes—and is ascribed to—biology in ways that both reflect and contribute to dominant racial ideology. By bringing together the research about race from the natural and social sciences, the course seeks to understand how biological and social factors interact to shape racial reality and explores the political and social implications for scientific inquiry.

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How Europeans evolved white skin

Posted in Articles, Europe, Health/Medicine/Genetics, Media Archive on 2015-04-06 01:26Z by Steven

How Europeans evolved white skin

Science
2015-04-02
DOI: 10.1126/science.aab2435

Ann Gibbons, Contributing Correspondent

ST. LOUIS, MISSOURI—Most of us think of Europe as the ancestral home of white people. But a new study shows that pale skin, as well as other traits such as tallness and the ability to digest milk as adults, arrived in most of the continent relatively recently. The work, presented here last week at the 84th annual meeting of the American Association of Physical Anthropologists, offers dramatic evidence of recent evolution in Europe and shows that most modern Europeans don’t look much like those of 8000 years ago.

The origins of Europeans have come into sharp focus in the past year as researchers have sequenced the genomes of ancient populations, rather than only a few individuals. By comparing key parts of the DNA across the genomes of 83 ancient individuals from archaeological sites throughout Europe, the international team of researchers reported earlier this year that Europeans today are a mix of the blending of at least three ancient populations of hunter-gatherers and farmers who moved into Europe in separate migrations over the past 8000 years. The study revealed that a massive migration of Yamnaya herders from the steppes north of the Black Sea may have brought Indo-European languages to Europe about 4500 years ago.

Now, a new study from the same team drills down further into that remarkable data to search for genes that were under strong natural selection—including traits so favorable that they spread rapidly throughout Europe in the past 8000 years. By comparing the ancient European genomes with those of recent ones from the 1000 Genomes Project, population geneticist Iain Mathieson, a postdoc in the Harvard University lab of population geneticist David Reich, found five genes associated with changes in diet and skin pigmentation that underwent strong natural selection…

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Breathing Race into the Machine: The Surprising Career of the Spirometer from Plantation to Genetics by Lundy Braun (review)

Posted in Articles, Book/Video Reviews, Health/Medicine/Genetics, History, Media Archive, United Kingdom, United States on 2015-04-03 19:37Z by Steven

Breathing Race into the Machine: The Surprising Career of the Spirometer from Plantation to Genetics by Lundy Braun (review)

Configurations
Volume 23, Number 1, Winter 2015
pages 127-130
DOI: 10.1353/con.2015.0000

Lindsey Andrews, Visiting Scholar of English
Center for Interdisciplinary Studies in Science and Cultural Theory
Duke University, Durham, North Carolina

Braun, Lundy, Breathing Race into the Machine: The Surprising Career of the Spirometer from Plantation to Genetics (Minneapolis: University of Minnesota Press, 2014).

Lundy Braun’s account of the ongoing and often invisible implementation of race-correction in pulmonary medicine is as much about the absence of the spirometer—a machine developed to measure lung function with accuracy—as it is about its presence. Breathing Race into the Machine: The Surprising Career of the Spirometer from Plantation to Genetics asks how it is possible that, well into the twenty-first century, doctors continue to use technologies that “correct” for racial differences in lung function despite no existing physiological difference. How did buttons establishing separate norms based on race and sex come to be a surreptitious, yet pervasive feature of diagnostic machinery? The answer lies in a much larger story about the desirability, across multiple domains and professions, of a technically precise means for measuring the elusive quality that physicians, scientists, and insurance companies came to think of as “vital capacity” or “fitness.” Building explicitly on Keith Wailoo’s Drawing Blood: Technology and Disease Identity in Twentieth-Century America (1997) and contributing to a growing body of literature on race in science and technology, Braun’s study “examine[s] the complex and contradictory historical processes by which differences such as race, class, and gender actually get embedded into the very architecture of scientific instruments” (p. xxi).

Braun tracks the proliferation of spirometric uses, from the machine’s earliest emergence as a tool for monitoring laborers’ fitness in the middle of the nineteenth century, through its development as a medical diagnostic tool in the twentieth century, to its contemporary role in adjudicating worker’s compensation claims. One of the most intriguing aspects of Braun’s book—and at times its most challenging feature—is its attempt to account for the ways in which the spirometer’s flexibility (rather than its specificity) as a precision tool and its unclear object of measurement (vital capacity) made it, in fact, such a powerful tool that would come to play a crucial global role in health- and insurance-policy decisions. What Braun ultimately shows is that separate though related epistemological problems regarding vital capacity emerged across multiple fields—including labor surveillance, fitness culture, and diagnostic medicine—to which precision and numeracy appeared to be the answer. The spirometer provided both. As Braun notes, spirometry was not central to any one discipline, but instead found myriad uses in physical education, military testing and training, and insurance assessment. “As its epistemological relevance faded in one domain,” she writes, “it was taken up, adapted, and investigated in another” (p. xxv). Whether shoring up Anglo-Saxon masculinity by establishing the superiority of upper-class white lungs in nineteenth-century physical culture or enforcing anti-black workers’ compensation policies that required blacks to demonstrate even lower lung functioning than similarly positioned white workers in order to receive remuneration, the capacity of the spirometer to produce numeric data was both its appeal in terms of authority and simultaneously its most easily racialized feature—a feature made invisible in the apparent “value neutrality” of a scientific virtue (a concept that Braun draws from Lorainne Daston and Peter Galison) like precision.

Tracing the international and professional border-crossing of the spirometer is one of the book’s primary accomplishments, but also one of its challenges for readers. In the course of seven chapters, Braun is tasked with moving back and forth from the twenty-first to the early nineteenth century, and from Wales, to the US South, to South Africa, negotiating a narrative that is neither straightforward nor linear, although always following a through-line in which assessment of the laboring body and management of the laboring class drive spirometric racialization. Early chapters cover the stabilization of whiteness as a meaning of lung-capacity measurements. In the first chapter, Braun shows how John Hutchinson, a Victorian scientist and early developer of the spirometer, reconfigured pulmonary studies in terms of physiological functioning rather than anatomical construction, thus tapping into growing investments in scientific experimentalism and the “quantifying spirit” of the Victorian era by adapting the spirometer’s use to large-scale population studies. Chapter 1 thus lays the groundwork for the third and fourth chapters, which also detail the ways in which lung-capacity measurements, along with anthropometry

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“General Heads,” Great Minds, and the Genesis of Scientific Racism

Posted in Anthropology, Articles, Health/Medicine/Genetics, History, Media Archive on 2015-03-23 01:02Z by Steven

“General Heads,” Great Minds, and the Genesis of Scientific Racism

Journal for Early Modern Cultural Studies
Volume 15, Number 2, Spring 2015
pages 112-118

Robin Runia, Assistant Professor of English
Xavier University of Louisiana, New Orleans, Louisiana

It is commonly presum’d that the Heat of the Climate wherein they live, is the reason, why so many Inhabitants of the Scorching Regions of Africa are Black; and there is this familiar Observation to Countenance this Conjecture, That we plainly see that Mowers, Reapers, and other Countrey-people, who spend the most part of the Hot Summer dayes expos’d to the Sun, have the skin of their Hands and Faces, which are the parts immediately Expos’d to the Sun and Air, made of a Darker Colour than before, and consequently tending to Blackness; And Contrarywise we observe that the Danes and some other people that Inhabit Cold Climates, and even the English who feel not so Rigorous a Cold, have usually Whiter faces than the Spaniards, Portugalls and other European Inhabitants of Hotter Climates. But this Argument I take to be far more Specious than Convincing. (153–54)

There is another Opinion concerning the Complexion of Negroes, that . . . the Blackness of Negroes [is] an effect of Noah’s Curse ratify’d by God’s, upon Cham; But though I think that even a Naturalist may without disparagement believe all the Miracles attested by the Holy Scriptures, yet in this case to flye to a Supernatural Cause, will, I fear, look like Shifting off the Difficulty, instead of Resolving it; for we enquire not the First and Universal, but the Proper, Immediate, and Physical Cause of the Jetty Colour of Negroes; And not only we do not find expressed in the Scripture, that the Curse meant by Noah to Cham, was the Blackness of his Posterity, but we do find plainly enough there that the Curse was quite another thing, namely that he should be a Servant of Servants, that is by an Ebraism, a very Abject Servant to his Brethren. . . . Nor is it evident that Blackness is a Curse, for Navigators tell us of Black Nations, who think so much otherwise of their own condition, that they paint the Devil White. Nor is Blackness inconsistent with Beauty, which even to our European Eyes consists not so much in Colour, as an Advantageous Stature, a Comely Symmetry of the parts of the Body, and Good Features in the Face. So that I see not why Blackness should be thought such a Curse to the Negroes, unless perhaps it be, that being wont to go Naked in those Hot Climates, the Colour of their Skin does probably, according to the Doctrine above deliver’d, make the Sunbeams more Scorching to them, than they would prove to a people of a White Complexion. (159–60)

Greater probability there is, That the Principal Cause (for I would not exclude all concurrent ones) of the Blackness of Negroes is some Peculiar and Seminal Impression. (161)

—Robert Boyle, Experiments and Considerations Touching Colours (1664)

The above extracts present Robert Boyle’s delineation of racialized difference, as produced and evaluated by the Royal Society; this delineation, production, and evaluation is the lifeblood of Cristina Malcolmson’s Studies of Skin Color in the Royal Society. Exploring the development of the modern notion of race within the context of colonialism, Malcolmson argues that “the attention to skin color in the Royal Society allowed racialization to develop and eventually flourish within the practices of the new science” (7). Specifically, attention to the imbrication of this process within institutional and economic commitments to British imperial dominance helps to fill in the gaps between an attention to skin color, consideration of its causes, and the dehumanization and subjugation of non-European individuals. Malcolmson’s focus on the Royal Society’s activities and publications and on Margaret Cavendish’s and Jonathan Swift’s reactions to them provides an important and nuanced contribution to the recent scholarship in this area as well as a call for additional work to be done.

The value of this volume lies in Malcolmson’s thorough presentation of compelling evidence and insightful close readings that expose the Royal Society’s complicity in the spread of racialized discourse and racist thought. In addition, Malcomson’s original contributions to scholarship on the historical construction of race include her critique of polygenesis as inherently racist and her methodical…

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Genetics: No evidence of role in racial mortality gap

Posted in Articles, Health/Medicine/Genetics, Media Archive on 2015-03-20 00:48Z by Steven

Genetics: No evidence of role in racial mortality gap

Science Daily: Your source for the latest research news
2015-03-16

There is still no evidence of genetic difference between blacks and whites to account for the health disparities in cardiovascular disease (CVD), according to a new study by McGill University researchers. Published in the American Journal of Epidemiology, the researchers suggest that after a decade of genetic studies, factors such as lifestyle, education and socio-economics — not genetics — are more promising avenues to understanding racial health disparities.

The researchers focused on cardiovascular disease, the largest contributor to the racial mortality gap, and conducted a systematic review for articles published over a seven year period in which genetic data from African and European populations were available. The team found no explanation for racial disease disparities amongst any of the hundreds of genetic variants reported.

“After nearly a decade of genome-wide association studies (GWAS), no assessment had yet been made of their contribution toward an explanation of the most prominent racial health disparities observed at the population level,” says Jay Kaufman, of the Department of Epidemiology, Biostatistics & Occupational Health in the Faculty of Medicine…

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The Evolution of the Idea of Race: From Scientific Racism to Genomics

Posted in Anthropology, Health/Medicine/Genetics, History, Live Events, Media Archive, Social Science on 2015-03-20 00:40Z by Steven

The Evolution of the Idea of Race: From Scientific Racism to Genomics

Oxford University Press Webinar
Oxford University Press
Friday, 2015-03-20, 18:00-19:00Z, 14:00-15:00 EDT

Join Oxford University Press on Friday, March 20th for a Webinar featuring Tanya Golash-Boza.

Tanya Golash-Boza is an Associate Professor in the School of Social Sciences, Humanities, and Arts at the University of California, Mereced, and the author of the acclaimed textbook, Race and Racisms: A Critical Approach.

In 1735, Swedish botanist Carolus Linnaeus divided the world into four groups: Americanus, Asiaticus, Europeanus, and Africanus. In the 1850s, Samuel George Morton measured human skulls to prove European superiority. His successor, Paul Broca, compared brain sizes. Psychologist R. M. Yerkes used IQ tests to the same end in the early 20th century, as did Herrnstein and Murray in the late 20th century. Today, scientists use genomics to prove there are biological differences between the races. What has changed and what has not? In this webinar, we will develop a sociological analysis of the evolution of the idea of race and of the persistence of racism.

For more information, click here.

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The Contribution of Genomic Research to Explaining Racial Disparities in Cardiovascular Disease: A Systematic Review

Posted in Articles, Health/Medicine/Genetics, Media Archive on 2015-03-18 01:31Z by Steven

The Contribution of Genomic Research to Explaining Racial Disparities in Cardiovascular Disease: A Systematic Review

American Journal of Epidemiology
First Published online: 2015-03-01
DOI: 10.1093/aje/kwu319

Jay S. Kaufman, Professor
Department of Epidemiology, Biostatistics, and Occupational Health
McGill University, Montreal, Quebec, Canada

Lena Dolman
McGill University, Montreal, Quebec, Canada

Dinela Rushani
McGill University, Montreal, Quebec, Canada

Richard S. Cooper, Anthony B. Traub Professor of Community and Family Medicine
Stritch School of Medicine
Loyola University, Chicago, Illinois

After nearly a decade of genome-wide association studies, no assessment has yet been made of their contribution toward an explanation of the most prominent racial health disparities observed at the population level. We examined populations of African and European ancestry and focused on cardiovascular diseases, which are collectively the largest contributor to the racial mortality gap. We conducted a systematic search for review articles and meta-analyses published in 2007–2013 in which genetic data from both populations were available. We identified 68 articles relevant to this question; however, few reported significant associations in both racial groups, with just 3 variants meeting study-specific significance criteria. For most outcomes, there were too few estimates for quantitative summarization, but when summarization was possible, racial group did not contribute to heterogeneity. Most associations reported from genome-wide searches were small, difficult to replicate, and in no consistent direction that favored one racial group or another. Although the substantial investment in this technology might have produced clinical advances, it has thus far made little or no contribution to our understanding of population-level racial health disparities in cardiovascular disease.

Read or purchase the article here.

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A reconsideration of the role of self-identified races in epidemiology and biomedical research

Posted in Articles, Health/Medicine/Genetics, Media Archive, United States on 2015-03-17 15:19Z by Steven

A reconsideration of the role of self-identified races in epidemiology and biomedical research

Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Available online: 2015-03-16
DOI: 10.1016/j.shpsc.2015.02.004

Ludovica Lorusso
Department of Political Science, Communication, Engineering and Information Technologies
University of Sassari, Italy
Department of Philosophy
University of San Francisco, San Francisco, California

Fabio Bacchini
Laboratory of Applied Epistemology, DADU
University of Sassari, Italy
Department of Philosophy
Stanford University, Palo Alto, California

Highlights

  • We explore the role of race in biomedicine and epidemiology.
  • We reject the use of race as a proxy for a genetic component to a complex disease risk.
  • Self-identified race and exposomic and epigenomic variation tend to match each other.
  • Self-identified race captures the effects of present and past racism on people’s health.

A considerable number of studies in epidemiology and biomedicine investigate the etiology of complex diseases by considering (self-identified) race as a relevant variable and focusing on the differences in risk among racial groups in the United States; they extensively draw on a genetic hypothesis—viz. the hypothesis that differences in the risk of complex diseases among racial groups are largely due to genetic differences covarying with genetic ancestry—that appears highly problematic in the light of both current biological evidence and the theory of human genome evolution. Is this reason for dismissing self-identified races? No. An alternative promising use of self-identified races exists, and ironically is suggested by those studies that investigate the etiology of complex diseases without focusing on racial differences. These studies provide a large amount of empirical evidence supporting the primacy of the contribution of non-genetic as opposed to genetic factors to the risk of complex diseases. We show that differences in race—or, better, in racial self-identification—may be critically used as proxies for differences in risk-related exposomes and epigenomes in the context of the United States. Self-identified race is what we need to capture the complexity of the effects of present and past racism on people’s health and investigate risk-related external and internal exposures, gene–environment interactions, and epigenetic events. In fact patterns of racial self-identifications on one side, and patterns of risk-related exposomes and epigenomes on the other side, constantly coevolve and tend to match each other. However, there is no guarantee that using self-identified races in epidemiology and biomedical research will be beneficial all things considered: special attention must be paid at balancing positive and negative consequences.

Read or purchase the article here.

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IRRPP Annual Bowman Lecture: Fatal Invention: Why The Politics of Race and Science Still Matters

Posted in Health/Medicine/Genetics, Live Events, Media Archive, Politics/Public Policy, Social Science, United States on 2015-03-11 16:52Z by Steven

IRRPP Annual Bowman Lecture: Fatal Invention: Why The Politics of Race and Science Still Matters

Institute for Research on Race and Public Policy
University of Illinois, Chicago
Student Center East
750 S. Halsted St, Room 302
Chicago, Illinois
2015-03-12, 16:00 CDT (Local Time)

Dorothy Roberts, Professor of Law and Sociology
University of Pennsylvania

Co-sponsors: Medical Education, Institute for the Humanities Health and Society Working Group, Gender & Women’s Studies, Sociology, Biocultures, Racialized Body Cluster, African American Studies

An acclaimed scholar of race, gender, and the law, Professor Dorothy Roberts is the fourteenth Penn Integrates Knowledge Professor, George A. Weiss University Professor, and the inaugural Raymond Pace and Sadie Tanner Mossell Alexander Professor of Civil Rights at University of Pennsylvania. She holds appointments in the Law School and Departments of Africana Studies and Sociology. Professor Roberts received her Doctor of Jurisprudence from Harvard Law School.

This lecture was established to honor Phillip J. Bowman’s contributions to UIC during his tenure as Director of IRRPP and Professor of African American Studies. It features national scholars of race, ethnicity, and public policy who provide timely analysis of issues of critical importance to the field and to communities of color.

For more information, click here.

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